Giants 38, Packers 10: Eli Manning passed for 249 yards and three touchdowns and Andre Brown and Ahmad Bradshaw added rushing scores as New York thumped visiting Green Bay in a meeting of the past two Super Bowl champions.

Manning threw a 16-yard touchdown to Rueben Randle and a 9-yard strike to Victor Cruz in the first half to help the Giants (7-4) build a 31-10 halftime lead. He iced it with a 13-yard scoring toss to Hakeem Nicks in the third quarter, passing Phil Simms for the franchise record with his 200th career touchdown pass.

The Giants have a two-game lead in the NFC East, while the Packers (7-4) dropped a game behind the Chicago Bears in the NFC North. The loss snapped a five-game winning streak for Green Bay, which managed just 317 total yards and committed two turnovers.

The offenses traded early punches, as Brown capped a long drive by the Giants on the opening series with a 2-yard touchdown run, and Aaron Rodgers and the Packers answered with a 61-yard touchdown pass to Jordy Nelson. But it was all New York from there.

Green Bay had the ball with a chance to get within one score by halftime, but Osi Umenyiora stripped Rodgers and Jason Pierre-Paul recovered for the Giants. Bradshaw scored from 13 yards out two plays later for a 31-10 lead.

GAME NOTEBOOK: The last time the Packers lost a regular-season game by more than 12 was a 51-29 loss to the Saints in Week 12 of the 2008 season. ... Manning had not thrown a touchdown pass in his previous three games. ... The Giants beat the Packers for just the second time in the past eight regular-season meetings.