BLACKSBURG, Va. -- No. 23 Duke had never won in Blacksburg before 2013.

Now the Blue Devils have done something that few teams ever have -- beaten Virginia Tech two straight times on its home field.

Duke beat Tech 45-43 in the first quadruple-overtime game in ACC history on Saturday. The Blue Devils (6-1) improved to 3-0 in ACC play for the first time since 1994 and for only the fifth time in school history.

"It's a milestone," Blue Devils tight end Erich Schneider said. "We've been talking about that all week, back-to-back.

"We wanted to win two times in Blacksburg. To win in this environment back-to-back is unbelievable. This is one of the greatest wins I've ever been a part of. I think it is the greatest win I've ever been a part of."

Schneider caught a 25-yard touchdown from quarterback Thomas Sirk in the fourth overtime to tie the score, and Sirk scored the two-point conversion run to give the Blue Devils the victory.

"It was a sprint-out pass, and they had a good call against our call, and they brought a lot of guys over to the right side of the field and it opened up a running lane back to the left," Sirk said.

Sirk passed for 270 yards and four touchdowns and had a team-high 109 rushing yards. Two of his touchdown passes went to wide receiver Max McCaffery, who had a team-high six catches for 94 yards.

In his first start since sustaining a broken collarbone in the season-opener, Virginia Tech quarterback Michael Brewer passed for 270 yards and three touchdowns.

Running back Travon McMillian rushed for a career-high 142 yards and two touchdowns on 29 carries for the Hokies. Tight end Bucky Hodges caught all three of Brewer's touchdown passes. He had five receptions for 101 yards.

"We just took what the defense gave us. (Offensive coordinator Scot Loeffler) called great plays to put me in a great position, and Brewer was dropping dimes," Hodges said.

Virginia Tech (3-5, 1-3) rallied to tie the game late in the fourth quarter on a 23-yard touchdown pass from Brewer to Hodges and a two-point conversion run by McMillian.

Brewer completed the touchdown pass while under duress. Hodges caught the high-lofting throw in the end zone while a flag was being thrown against Duke for pass interference.

The Blue Devils were called for pass interference on Virginia Tech's first two two-point attempts. McMillian converted the third try with a short run up the middle.

Duke drove into field goal range but Ross Martin's 46-yard field goal attempt bounced off the right upright with 1:04 remaining.

The Hokies bungled their final series of regulation, failing to notice the clock running down after a pass play on which wide receiver Cam Phillips appeared to get out of bounds but didn't.

The officials ruled that Phillips' forward progress was stopped inbounds before he stepped out. When Tech finally noticed the clock and called timeout, only two seconds remained in regulation.

"We thought the clock had stopped, and all of a sudden, the clock was still running," Tech coach Frank Beamer said.

Hokies kicker Joey Slye was short on a 67-yard field goal attempt as the clock ran out in regulation.

Martin, who missed two of his three field goal attempts in regulation, booted field goals of 38 and 20 yards in overtime.

Slye had three field goals, including kicks of 37 and 40 yards in overtime.

The Hokies took a 43-37 lead at the start of the fourth overtime on McMillian's one-yard touchdown run. Brewer's two-point pass attempt failed.

Duke led 21-10 after Shaun Wilson's 58-yard third quarter touchdown run.

Wilson got to the edge and cut upfield. He juked one defender and made freshman cornerback Terrell Edmunds miss near the 20-yard line before running the rest of the way untouched.

The Hokies cut the deficit to 21-16 with a 20-play, 95-yard drive that burned 9:46 of the clock. McMillian took a direct snap and scored on a two-yard run with 27 seconds remaining in the third quarter.

Virginia Tech made the questionable decision to go for two, and backup quarterback Brenden Motley threw incomplete on the conversion attempt.

Martin converted a 41-yard field goal attempt with 11:48 remaining in the fourth quarter.

Duke led 14-10 at halftime.

The Blue Devils scored on their first two possessions, capping both with touchdown passes from Sirk to McCaffrey.

Virginia Tech topped off a successful first drive with a 16-yard touchdown pass from Brewer to tight end Bucky Hodges.

The Hokies added Slye's 44-yard field goal early in the second quarter to cut the Blue Devils' lead to 14-10.

Duke had a chance to add to its lead late in the second quarter, but Martin missed a 29-yard field goal attempt wide left with 2:53 remaining before halftime.

NOTES: Virginia Tech's 9-minute, 46-second third-quarter drive was the longest drive in the 29-year Frank Beamer era. ... RB Shaun Wilson's third-quarter touchdown run was his fourth career rushing touchdown of 50 or more yards. ... TE Bucky Hodges' first-quarter touchdown reception was only the fourth passing touchdown allowed by Duke all season. ... K Ross Martin had converted 15 straight field goal attempts before his second-quarter miss. It was his first failed field goal attempt since the Blue Devils' 17-16 loss to the Hokies last November. ... Virginia Tech senior defensive tackle Corey Marshall returned to the field after missing the previous two games because of a hamstring injury. He did not start but entered in the first quarter.