Seymour rushed for 89 yards on 20 carries and Kimbrow added 75 yards on 13 carries as Vanderbilt (9-4) scored 17 straight points in the fourth quarter and recorded back-to-back nine-win seasons for the first time in school history. Jordan Matthews had five catches for 143 yards and two touchdowns - all in the first half - for the first multi-touchdown game of his career.

John O'Korn went 20-of-47 for 228 yards and two touchdowns and two interceptions for Houston (8-5), which scored on four straight third-quarter possessions to tie game at 24. Markeith Ambles had six catches for 105 yards and a touchdown and Deontay Greenberry added six catches for 96 yards and a score.

Matthews had a pair of 50-yard touchdown catches in the first half and quarterback Patton Robinette scored on an 8-yard run four plays after a Houston fumble as Vanderbilt jumped to a 24-0 halftime lead. Houston's third-quarter scoring spree started with Robinette's fumble at the Vanderbilt 14, setting up Kenneth Farrow's 6-yard TD run on the next play.

O'Korn added a 6-yard TD pass to Ambles and a 67-yard scoring pass to a wide-open Greenberry to tie the game with 19 seconds left in the third quarter, in which Houston outgained Vanderbilt 309-47. Kimbrow broke the tie with a 21-yard touchdown run with 9:28 left and interceptions by Jahmel McIntosh and Andre Hal led to 10 more Commodore points to seal the win.

GAME NOTEBOOK: Vanderbilt outgained Houston 232-22 in the first half and held the Cougars to one first down. ... Houston forced three turnovers to finish the year with 43 takeaways and a plus-25 turnover margin. ... Robinette finished 6-of-19 for 154 yards, two touchdowns and two interceptions and didn't complete a pass after the second Matthews' touchdown, finishing the game missing seven straight attempts.